A Perfusion Bioreactor for Longitudinal Monitoring of Bioengineered Liver Constructs
نویسندگان
چکیده
منابع مشابه
Design of a Novel, MRI-compatible Bioreactor for Longitudinal Monitoring of Mechanically Conditioned Engineered Cardiovascular Constructs
Introduction It has been demonstrated that in order for engineered tissues to be suitable for implantation and remain functional long-term, they may have to be preconditioned in dynamic mechanical environments [1]. While bioreactor devices have been custom built for this purpose [2], to date, no device offers the possibility of: a) the exertion of coupled/decoupled flow-stretch-flexure (FSF) st...
متن کاملRapid magnetic cell delivery for large tubular bioengineered constructs.
Delivery of cells into tubular tissue constructs with large diameters poses significant spatial and temporal challenges. This study describes preliminary findings for a novel process for rapid and uniform seeding of cells onto the luminal surface of large tubular constructs. Fibroblasts, tagged with superparamagnetic iron oxide nanoparticles (SPION), were directed onto the luminal surface of tu...
متن کاملInfluence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: a review.
Bone tissue engineering aims to generate clinically applicable bone graft substitutes in an effort to ease the demands and reduce the potential risks associated with traditional autograft and allograft bone replacement procedures. Biomechanical stimuli play an important role under physiologically relevant conditions in the normal formation, development, and homeostasis of bone tissue--predomina...
متن کاملDevelopment and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs.
Osteoarthritis is a severe socio-economical disease, for which a suitable treatment modality does not exist. Tissue engineering of cartilage transplants is the most promising method to treat focal cartilage defects. However, current culturing procedures do not yet meet the requirements for clinical implementation. This article presents a novel bioreactor device for the functional tissue enginee...
متن کاملMicroscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions
The accurate prediction of hepatotoxicity demands validated human in vitro models that can close the gap between preclinical animal studies and clinical trials. In this study we investigated the response of primary human liver cells to toxic drug exposure in a perfused microscale 3D liver bioreactor. The cellularized bioreactors were treated with 5, 10, or 30 mM acetaminophen (APAP) used as a r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanomaterials
سال: 2021
ISSN: 2079-4991
DOI: 10.3390/nano11020275